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Kirby s nutrition science7/1/2023 Although traditional linear, reductionist methods have contributed greatly to our understanding of nutritional factors and their contribution to various diseases, the ability of these methods to examine complex reciprocal relationships between, for example, dietary intake, activity levels, and manifestation of disease, is limited. For example, the potency of a nutrient is determined by the genetic makeup, age, and health status of the host 1 by the bioavailability of the nutrient, which is affected by conditions associated with growing, harvesting, storing, and preparing food for consumption 2 and by the timing, frequency, and duration of dose and contextual factors (e.g., foods, medications, and diseases that aid or hinder absorption 3). The field of nutrition science is complex in that a large number of factors interact to produce an outcome of interest.
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